Detection of Cytomegalovirus (CMV) in Saliva of Congenitally Infected Neonates
نویسندگان
چکیده
منابع مشابه
Identification of Human Cytomegalovirus pUL27 R233 point mutation using PCR-RFLP
Background and Aims: Human Cytomegalovirus (HCMV) is one of the life-threatening agents in immunosuppressed patients and congenitally infected neonates in the world. Mutations in UL27 were suggested to confer low- to high-grade Maribavir (MBV) resistance. As pUL27 R233S variation may involve in either MBV-resistance, we aimed to establish a method for identifying R233 coding sequence mutation...
متن کاملFeasibility of Using Saliva as a Screening Specimen for Detection of Human Cytomegalovirus(hcmv) in Newborns
Previous studies have shown that saliva is an important specimen for the diagnosis of congenital Cytomegalovirus (CMV). It is not only easy to collect without trauma to the newborn but neonates shed large volume of the virus in their saliva. Saliva which usually carry high viral load in infected patients especially in children, contain several components which inhibit the sensitivity of Polymer...
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Two protocols for the extraction of cytomegalovirus (CMV) DNA and two methods for the amplification of CMV DNA in dried blood spots were evaluated for the retrospective diagnosis of congenital CMV infection. During the period from 1996 to 2006, a urine screening program detected 76 congenitally infected neonates. Stored Guthrie cards with blood from 55 cases and 12 controls were tested. Two spo...
متن کاملImmunoglobulin G to virus-specific early antigens in congenital, primary, and reactivated human cytomegalovirus infections.
Immunoglobulin G antibody to human cytomegalovirus (CMV)-specific early antigens (EA-Ab) was determined by the immunoperoxidase antibody technique in several cases of congenital, primary, and reactivated CMV infections. Mothers of congenitally infected infants and a group of leukemic children and pregnant women were also studied. In 11 cases of congenital infection, CMV EA-Ab was always associa...
متن کاملEvaluation of the Prevalence of Congenital Cytomegalovirus Infection and its Clinical Outcomes in Neonates Born in Vali-e-Asr Hospital of Birjand, Iran
Background Cytomegalovirus (CMV) has been known as the most common cause for congenital infections worldwide which can lead to death in fetus and neonates as well as neuropsychiatric deficits. The aim of this study was to determine the prevalence of congenital CMV infection in newly born neonates and to evaluate the medical outcomes. Materials and Methods In this cross-sectional study, 868 neon...
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2017